Silica Gel Filler for Column Chromatography 230-400mesh

• Customization: Available
• Purity: 99%
• Active Ingredient Content: Sio2
• CAS No.: 7631-86-9
• Color: White
• Formula: Msio2.Nh2o
• Lod: 2%, 5%
• Effect: Improve The Effect of Color
• Material: Silica Gel
• Structure Feature: Powder
• Usage: Filter Media/Filtration Agent
• Source: Sio2
• Absorption Capacity: More Than 90%
• Type: Porous Silicone Filler
• Transport Package: 25kg/Drum, 500kg/Super Sack
• Specification: 60-100, 100-200, 70-230, 230-400, 400-1000mesh
• Trademark: TZ
• Origin: China
• HS Code: 281122
• Production Capacity: 200tons/M

Product Description

Silica Gel Filter Media-Column Chromatography Silica Gel

Product Description

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In pharmaceutical production, chromatography silica gel is widely used due to its high adsorption, chemical stability, and controllable pore diameter:
1, Separation and purification of active ingredients in traditional Chinese medicine
Natural medicine extraction: to separate active ingredients such as alkaloids, flavonoids, saponins, etc. from traditional Chinese medicine, and meantime to achieve high-purity extraction through adsorption retention time differences.
Impurity removal: Remove interfering substances such as pigments and tannins from the extraction solution to improve the purity of the drug.
2, Chemical synthesis drug refining
Intermediate purification: Separate and purify intermediates during the synthesis process to remove by-products and residual catalysts.
Chiral Separation: Utilizing the differential adsorption of silanol groups on the surface of silica gel to separate enantiomers (such as chiral drugs).
3, Biopharmaceutical field
Peptide and protein purification: Large pore silica gel (such as C-type, pore size>10nm) is used to purify peptides, proteins, and antibiotics with molecular weights ranging from 500 to 40000.
Separation of nucleic acid substances: Purification of biological macromolecules such as oligonucleotides and nucleotides.
4, API Preparation
Final product refinement: Remove trace impurities through gradient elution technology to ensure that the raw material meets pharmacopoeia standards.
Solvent residue control: adsorb residual organic solvents (such as methanol, ethyl acetate).
5, Medicinal excipients and carriers
Catalyst carrier: an inert carrier used for solid-phase synthesis or catalytic reactions.
Drug release materials: Use their porous structure to control the drug release rate.

Key parameters for technical selection:

Application	Silica gel	Specifications
Small molecule (≤ 500Da)	Fine/medium pore (A/B)	Pore diameter: 2-7nm Particle size: 200-400mesh
Large molecule biopharmaceutical	Wide pore (C)	Pore diameter: 9nm+ Particle size: 100-200mesh
High purity API (Active Pharmaceutical Ingredients)	Reagent grade (high purity)	High purity with low metal residue and high BET (specific surface area)

Note: it is necessary to optimize the pore diameter, particle size, and elution system of silica gel based on the polarity, molecular weight, and separation scale of the target molecule.

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